Xin Hua

    Department of Cell Biology

    2006. 10

    Cell BiologyCell Proliferation and

    The Cell CycleⅠ. Different types of Cell proliferation

    1. Amitosis (无丝分裂)

    2. mitosis (有丝分裂)

    3. Meiosis (减数分裂)

    Cell Division1. amitosis ( 无丝分裂)2. mitosis (有丝分裂)3. meiosis (减数分裂)Ⅱ.cell proliferation cycle (cell cycle)

    The whole process of the completion of cell prolifferation

    through cell growth and division .interphase

    G1 ：pre-synthetic phase

    S ： DNA synthetic phase

    G2： post--synthetic phase

    Mitoticphase

    Prophase

    Metaphase

    Anaphase

    Telophase

    cell cycleG1：pre-synthetic phase

    S： DNA synthetic phase

    G2： post--synthetic phase

    M： mitotic phase

    Cell cycle time :

    Tc、TG1

    、Ts、T

    G2

    、TM

    1、The four successive phases of a cell cycle4

    2

    DNA

    G1 S G2+M G1

    (1) Chromosome cycle

    Chromosome Replication and Separation

    S 2

    M G1

    S

    G2

    M(2)Cytoplasmic cycle

    Growth phase

    (G1、S、G2) (M)

    Cell cycle(3)Centriole cycleCentriole cycle2、New concept of cell cycle compartment(细胞周期室)

    G1T:过渡相

    G0:静止相

    G1D:分化相

    M M

    G1A

    S

    G2

    G0

    G1T

    G1T

    S0

    ST

    ST

    G20

    G2T

    G2T

    G1D

    R

    G1B

    G13、Cell cycle time

    TC=20-30 h

    TG1=10-15 h

    TS=6-8 h

    TG2-3-6 h

    TM=0.5-1 h小鼠消化道上皮干细胞的周期时间(hour)

    细胞所在部位 TC

    TG1 TS+ TG2

    + TM

    口腔黏膜 85 75 10

    食道 181 171 10 ......