中华医学会第八次全国消化疾病学术会议论文汇编 青年分会场

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    ·分会场专题发言

    Translational Medicine——From Bedside to Bench

    Jie Liu M.D, Ph.D.

    Depart. of Digestive Diseases and State Key Laboratory for Cancer Biology,Xijing Hospital, The Fourth Military Medical University, Xi’an, China.710032

    Despite unprecedented opportunities in basic and clinical research, the gap between them

    has widened. To bridge the gap between these disciplines, a novel conception,“translational medicine” emerged. It can be defined as a discipline in which basic

    scientists provide clinicians with new tools for use in patients and for assessment of their

    impact, and clinical researchers make novel observations about the nature and

    progression of disease that often stimulate basic investigations.

    Translational research has been proven to be a powerful process that drives the clinical

    research engine since its emergence. It helps translating basic science advances to

    improved patient care. Discovery of novel biomarkers for some given diseases is a

    prerequisite content of translational medicine, which may promote the development of

    new drugs effectively. In our practice, 4 novel HBV-related genes, successfully cloned by

    our group, have been demonstrated elevated expression in the canceration group

    compared with non-canceration group. Combinational serum screening or even single

    protein along can be served as early predictor and prognostic marker for HCC, suggesting

    the promising prospect of clinical application of these novel genes. Assay kit for predicting

    HCC based on these genes is ongoing.

    So far, translational medicine has rather been a linear concept rooted in traditional

    approaches to provide therapies for diseases (from bench to bedside), while

    patient-oriented research that involves understanding the underlying cause of disease

    and its treatments (from bedside to bench) is often regrettably neglected. In practice,translational medicine should be regarded as a two-way road: Bench to Bedside and

    Bedside to Bench. Further comprehension of pathogenesis of diseases may trigger new

    therapeutic strategy and should be paid more attention. One of our clinical studies

    published on Nature Clin Pract Oncol (2005) can be served as a paradigm of bedside to

    bench, which is the first Chinese clinical study published on the journal of Nature series.

    Most importantly, this study is recommended as CME (continuing medical education) for

    the clinicians in American and England. 青年分会场 中华医学会第八次全国消化疾病学术会议论文汇编

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    INTERDISCIPLINARY: FROM GUT TO BRAIN

    Li-Ping Duan

    Department of Gastroenterology, Third Hospital, Peking University, Beijing

    The conception of comorbidity was first put forward by Feinstein in 1970s, it refers the

    presence of coexisting or additional diseases with reference to an initial diagnosis or with

    reference to the index condition that is the subject of study. There is an increased

    prevalence of psychiatric disorders in clinic patients with some FGIDs (40%-60%). When

    the patients who suffer from psychiatric disorders have the complains characterized by

    somatization disorders, their symptoms would be very difficult to get improved without

    proper pharmacologic treatment. Traditionally, the gastroenterologist focus on the GUT,but the BRAIN could not be neglected. Knowledge about the psychosocial field of FGIDs ......