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中山大学肿瘤防治中心胸科 傅剑华
【 摘要 】 为了进一步提高局部晚期食管癌的疗效，人们进行了多种治疗模式的探索，如术前放疗、术前化疗、术前放化疗、术后放疗、术后化疗等。目前以食管癌术前 放化( Chemoradiotherapy, CRT ) 并手术的治疗模式特别引人关注，但文献报告的多个随机对照研究 结果显示其价值颇有争议。有趣的是：尽管目前对术前 CRT 提高食管癌生存率的价值未达共识，但国际上有许多著名的学术组织或机构，如 NCCN 、 ASCO 、 M.D Anderson Cancer Center 、 EORTC 等已经把 术前 CRT 并手术治疗局部晚期或潜在可切除的食管癌写入治疗指引。 可见， 术前放化疗并手术的治疗模式是目前研究的热点，亦是一个非常有前景的治疗模式。文中亦介绍了 中山大学肿瘤防治中心进行的 术前放化疗加手术治疗局部晚期食管癌的 II 期临床研究的结果 。
【关键词】 食管癌；放化疗；手术
【 Abstract 】 Many therapeutic patterns had been used to improve the therapeutic results of locally advanced esophageal carcinoma(EC),such as preoperative radiotherapy ， preoperative chemotherapy, postoperative radiotherapy and postoperative chemotherapy. At present more and more researchers pay attention to the new pattern, preoperative chemoradiotherapy followed by surgery. Though several random control trials showed the controversial results, many international academic organizations and constitutions, including NCCN 、 ASCO 、 M.D Anderson Cancer Center 、 EORTC, have adopted this pattern, of which the value on survival rate have not reached a consensus, into their therapeutic guideline for EC. So the pattern of preoperative chemoradiotherapy followed by surgery is a focus for research and also a promising therapeutic pattern. There was a phase II trail performed in the Cancer Center of Zhongshan University to evaluate the value of preoperative chemoradiotherapy followed by surgery in the treatment of locally advanced EC and the results were reported in this article.
【 摘要 】 为了进一步提高局部晚期食管癌的疗效，人们进行了多种治疗模式的探索，如术前放疗、术前化疗、术前放化疗、术后放疗、术后化疗等。目前以食管癌术前 放化( Chemoradiotherapy, CRT ) 并手术的治疗模式特别引人关注，但文献报告的多个随机对照研究 结果显示其价值颇有争议。有趣的是：尽管目前对术前 CRT 提高食管癌生存率的价值未达共识，但国际上有许多著名的学术组织或机构，如 NCCN 、 ASCO 、 M.D Anderson Cancer Center 、 EORTC 等已经把 术前 CRT 并手术治疗局部晚期或潜在可切除的食管癌写入治疗指引。 可见， 术前放化疗并手术的治疗模式是目前研究的热点，亦是一个非常有前景的治疗模式。文中亦介绍了 中山大学肿瘤防治中心进行的 术前放化疗加手术治疗局部晚期食管癌的 II 期临床研究的结果 。
【关键词】 食管癌；放化疗；手术
【 Abstract 】 Many therapeutic patterns had been used to improve the therapeutic results of locally advanced esophageal carcinoma(EC),such as preoperative radiotherapy ， preoperative chemotherapy, postoperative radiotherapy and postoperative chemotherapy. At present more and more researchers pay attention to the new pattern, preoperative chemoradiotherapy followed by surgery. Though several random control trials showed the controversial results, many international academic organizations and constitutions, including NCCN 、 ASCO 、 M.D Anderson Cancer Center 、 EORTC, have adopted this pattern, of which the value on survival rate have not reached a consensus, into their therapeutic guideline for EC. So the pattern of preoperative chemoradiotherapy followed by surgery is a focus for research and also a promising therapeutic pattern. There was a phase II trail performed in the Cancer Center of Zhongshan University to evaluate the value of preoperative chemoradiotherapy followed by surgery in the treatment of locally advanced EC and the results were reported in this article.