CORRECTION
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《毒物学科学杂志》
Comparison of Non-Human Primate and Human Whole Blood Tissue Gene Expression Profiles
doi:10.1093/toxsci/kfi243
Toxicological Sciences 87, 306–314, 2005
In our paper "Comparison of non-human primate and human whole blood tissue gene expression profiles" which was published ahead of print on June 23, 2005 (doi:10.1093/toxscikfi243) and is printed in the September 2005 issue of the journal (Toxicol. Sci. 84: 306–314) we reference the work of Wang et al. 2004. Their paper, entitled "Identification and utilization of inter-species conserved (ISC) probesets on Affymetrix human Genechip platforms for the optimization of the assessment of expression patterns in non human primate (NHP) samples" was published in BMC Bioinformatics 5, 165, 2004.
Although we cite Wang et al. 2004 in our introduction and discussion, we failed to give appropriate attribution to text in our discussion taken from that paper. We sincerely regret our failure to properly cite these authors' work and wish to correct this by attributing the following text in our discussion to them:
A single gene does not necessarily generate a single transcript. Splicing variants are very common in the human, and humans and NHPs may use different splicing strategies in some genes.
Chismar and colleagues used the U95Av2 human genechip and compared the expression patterns of humans with rhesus. They concluded that the percentage of detected genes (genes called ‘present’) in the rhesus brain is lower than that of human brain, and that this is especially true for genes with lower signal intensity. Caceres and colleagues used the HG-U95Av2 human genechip to identify upregulated genes in the human cortex compared with those of the NHPs. Since sequence divergence could lead to an underestimation of expression levels in NHPs, they excluded 4572 probes that exhibited different hybridization behavior between two sets of samples in order to reduce false positives. However, this analysis is solely based on probe intensities.(James F. Dillman, III and Christopher S.)
doi:10.1093/toxsci/kfi243
Toxicological Sciences 87, 306–314, 2005
In our paper "Comparison of non-human primate and human whole blood tissue gene expression profiles" which was published ahead of print on June 23, 2005 (doi:10.1093/toxscikfi243) and is printed in the September 2005 issue of the journal (Toxicol. Sci. 84: 306–314) we reference the work of Wang et al. 2004. Their paper, entitled "Identification and utilization of inter-species conserved (ISC) probesets on Affymetrix human Genechip platforms for the optimization of the assessment of expression patterns in non human primate (NHP) samples" was published in BMC Bioinformatics 5, 165, 2004.
Although we cite Wang et al. 2004 in our introduction and discussion, we failed to give appropriate attribution to text in our discussion taken from that paper. We sincerely regret our failure to properly cite these authors' work and wish to correct this by attributing the following text in our discussion to them:
A single gene does not necessarily generate a single transcript. Splicing variants are very common in the human, and humans and NHPs may use different splicing strategies in some genes.
Chismar and colleagues used the U95Av2 human genechip and compared the expression patterns of humans with rhesus. They concluded that the percentage of detected genes (genes called ‘present’) in the rhesus brain is lower than that of human brain, and that this is especially true for genes with lower signal intensity. Caceres and colleagues used the HG-U95Av2 human genechip to identify upregulated genes in the human cortex compared with those of the NHPs. Since sequence divergence could lead to an underestimation of expression levels in NHPs, they excluded 4572 probes that exhibited different hybridization behavior between two sets of samples in order to reduce false positives. However, this analysis is solely based on probe intensities.(James F. Dillman, III and Christopher S.)