红景天、蛹虫草、大黄配伍治疗代谢综合征的实验研究Ⅱ——治疗肥胖症作用(4)
[12] 李娟，陈玲，张晓琳， 等. 红景天、蛹虫草、大黄配伍治疗代谢综合征的实验研究I ——改善胰岛素抵抗[J]. 中国中药杂志，2012，37(11)：1614.
Investigation of a compound， compatibility of Rhodiola crenulata，Cordyceps militaris， and Rheum palmatum， on metabolic
syndrome treatment II ——improving obesity
TIAN Jinying， CHEN Ling， ZHANG Xiaolin， LI Juan， HAN Jing， FU Jianyang，YANG Xiaomeng， ZHANG Peicheng， YE Fei*
(Beijing Key Laboratory of New Drug Mechanism of Action and Pharmacodynamic Evaluation， Chinese Academy of
Medical Sciences， Beijing Union Medical College， Institute of Materia Medica， Beijing 100050， China)
[Abstract] To investigate the effect of compound FF16， compatibility of Rhodiola crenulata， Cordyceps militaris， and Rheum palmatum， on obesity， both the insulin resistant obese IRF mouse model induced by high fat diet and the spontaneous type 2 diabetes KKAy obese mouse model were used. The results showed that the body weights and the energy uptake were markedly reduced by compound FF16 in both IRF mice in dosedependent manner and KKAy mice， respectively. Meanwhile， with the administration of FF16， the hypercholesterolemia and the hypertriglyceridemia were improved significantly in KKAy mice； and the levels of serum cholesterol and fatty index were decreased obviously， and the value of serum HDLC was increased significantly in IRF mice， respectively. Moreover， the activity of αglycosidase was inhibited by compound FF16 in vitro. In conclusion， FF16 could improve the obesity by inhibiting αglycosidase activity.
[Key words] traditional Chinese medicine compound FF16； obesity； IRF mice； KKAy mice； αglycosidase
doi：10.4268/cjcmm20130930
[责任编辑 陈玲], 百拇医药(田金英，陈玲，张晓琳，李娟，韩静，付建阳，杨晓萌，张培成，叶菲)
Investigation of a compound， compatibility of Rhodiola crenulata，Cordyceps militaris， and Rheum palmatum， on metabolic
syndrome treatment II ——improving obesity
TIAN Jinying， CHEN Ling， ZHANG Xiaolin， LI Juan， HAN Jing， FU Jianyang，YANG Xiaomeng， ZHANG Peicheng， YE Fei*
(Beijing Key Laboratory of New Drug Mechanism of Action and Pharmacodynamic Evaluation， Chinese Academy of
Medical Sciences， Beijing Union Medical College， Institute of Materia Medica， Beijing 100050， China)
[Abstract] To investigate the effect of compound FF16， compatibility of Rhodiola crenulata， Cordyceps militaris， and Rheum palmatum， on obesity， both the insulin resistant obese IRF mouse model induced by high fat diet and the spontaneous type 2 diabetes KKAy obese mouse model were used. The results showed that the body weights and the energy uptake were markedly reduced by compound FF16 in both IRF mice in dosedependent manner and KKAy mice， respectively. Meanwhile， with the administration of FF16， the hypercholesterolemia and the hypertriglyceridemia were improved significantly in KKAy mice； and the levels of serum cholesterol and fatty index were decreased obviously， and the value of serum HDLC was increased significantly in IRF mice， respectively. Moreover， the activity of αglycosidase was inhibited by compound FF16 in vitro. In conclusion， FF16 could improve the obesity by inhibiting αglycosidase activity.
[Key words] traditional Chinese medicine compound FF16； obesity； IRF mice； KKAy mice； αglycosidase
doi：10.4268/cjcmm20130930
[责任编辑 陈玲], 百拇医药(田金英，陈玲，张晓琳，李娟，韩静，付建阳，杨晓萌，张培成，叶菲)