糖尿病肾病肾组织炎症信号通路p38MAPK的调节机制及中药的干预作用(6)
Nanjing University Medical School， Nanjing 210008， China；
3.Yichun Hospital of Traditional Chinese Medicine， Yichun 336000， China；
4.Department of Molecular Signaling University of Yamanashi， Yamanashi 409-3898， Japan)
[Abstract] It is reported，in the process of diabetic nephropathy(DN)，inflammatory-related p38 mitogen-activated protein kinase(MAPK)signaling pathway has a close relationship with renal injury.On the one hand，many factors in the upstream including hyperglycemia，abnormal hemodynamics，oxidative stress，and pro-inflammatory cytokines could activate p38MAPK signaling pathway.On the other hand，the activated p38MAPK signaling pathway could lead to renal damage via activating inflammatory cells，inducing the expression of inflammatory mediators，and intervening cytokines production.CHM could intervene p38MAPK signaling pathway through multi-ways，including inhibiting inflammatory cytokines expression，regulating phosphorylated p38MAPK(p-p38MAPK)expression，and reducing fibrogenic factors expression.
[Key words] diabetic nephropathy； Chinese herbal medicine； p38 mitogen-activated protein kinase； signaling pathway
doi：10.4268/cjcmm20131409, http://www.100md.com(陈好利 万毅刚 赵青 黄燕如 史喜苗 孟宪杰 姚建)
3.Yichun Hospital of Traditional Chinese Medicine， Yichun 336000， China；
4.Department of Molecular Signaling University of Yamanashi， Yamanashi 409-3898， Japan)
[Abstract] It is reported，in the process of diabetic nephropathy(DN)，inflammatory-related p38 mitogen-activated protein kinase(MAPK)signaling pathway has a close relationship with renal injury.On the one hand，many factors in the upstream including hyperglycemia，abnormal hemodynamics，oxidative stress，and pro-inflammatory cytokines could activate p38MAPK signaling pathway.On the other hand，the activated p38MAPK signaling pathway could lead to renal damage via activating inflammatory cells，inducing the expression of inflammatory mediators，and intervening cytokines production.CHM could intervene p38MAPK signaling pathway through multi-ways，including inhibiting inflammatory cytokines expression，regulating phosphorylated p38MAPK(p-p38MAPK)expression，and reducing fibrogenic factors expression.
[Key words] diabetic nephropathy； Chinese herbal medicine； p38 mitogen-activated protein kinase； signaling pathway
doi：10.4268/cjcmm20131409, http://www.100md.com(陈好利 万毅刚 赵青 黄燕如 史喜苗 孟宪杰 姚建)