GDM孕妇血清及脐血RBP4与胎儿体重的关系(1)
【摘要】目的：观察妊娠晚期孕妇血清及脐血视黄醇结合蛋白4(RBP4)在妊娠期糖尿病(GDM)及正常妊娠中是否存在差异，并探讨其与胎儿体重的关系。方法:选择性行剖宫产术的GDM孕妇20例为病例组，同期糖耐量正常孕妇20例为对照组。分别检测两组血清及脐血中RBP4水平，总胆固醇及甘油三酯水平，并记录胎儿出生体重。运用SPSS17.0对结果进行统计分析。结果：(1)GDM组血清及脐血RBP4水平均高于正常组，两组比较，差异有显著性意义(P<0.05;P=0.01)；新生儿脐血RBP4水平明显低于血清RBP4水平，两者比较，差异有显著性意义(P<0.01)；(2)与正常组相比，GDM组胎儿体重高于正常组，差异有显著性(P<0.05)；(3)脐血RBP4水平与新生儿出生体重呈正相关(r=0.327,P<0.05)。结论：妊娠期糖尿病时血清及脐血RBP4水平上升，且与胎儿体重正相关，提示RBP4与妊娠期糖尿病密切相关，但具体机制有待进一步研究。
【关键词】妊娠期糖尿病；视黄醇结合蛋白4(RBP4)；胎儿体重
, 百拇医药
【中图分类号】R714.256 【文献标识码】A 【文章编号】1004-7484(2012)10-0004-01
【Abstract 】Objective:To observe the changes of retinol binding protein 4(RBP4) in maternal serum levels and cord blood, and to assess their relationship with fetal weight in late trimester pregnant women with gestational diabetes mellitus(GDM).Methods:40 pregnant women who underwent elective cesarean section were recruited, including 20 with GDM and 20 with normal glucose tolerance test(NGT group). The serum and cord blood concentrations of RBP4 and total cholesterol,triglyceride were measured. Fetal weight were recorded. Statistical analysis was made by SPSS17.0.Results: (1)RBP4 levels both in maternal serum and cord blood were significantly higher in GDM group than in NGT group. (P<0.05;P=0.01); the cord blood concentrations of RBP4 were significantly lower than maternal serum(P<0.01); (2)compared with the control group, GDM group had heavier fetal weight (P<0.05);(3) The cord blood concentrations of RBP4 were also positively correlated with fetal weight (r=0.327,P<0.05); Conclusion: Maternal serum and cord blood RBP4 levels in GDM women had significant difference with NGT pregnancy women, and had positive correlation with fetal weight.This research hinted that RBP4 was closely correlated with GDM, and further study is needed to clarify its mechanism.
, 百拇医药
【Key words】Gestational diabetes mellitus(GDM);Retinol binding protein 4(RBP4); fetal weight
妊娠期糖尿病(GDM)是指妊娠期首次发现或发生的糖代谢异常。GDM对孕妇及胎儿均可造成不良影响。其发病机理尚未完全明确。近年来的研究表明,脂肪组织可分泌多种生物活性物质,称为脂肪因子。这些细胞因子与糖脂代谢的调节有重要关系。视黄醇结合蛋白4(RBP4)是一种新发现的脂肪因子，研究发现其与糖脂代谢密切相关。RBP4与妊娠期糖尿病的关系报道较少且有争议。本研究对GDM患者血清及脐血中的RBP4进行检测，以探讨RBP4与妊娠期糖尿病及胎儿体重的关系。
1 资料与方法
1.1 研究对象
依据美国糖尿病协会GDM标准进行诊断。选择2010年7月至2011年1月在本院门诊产前检查并行选择性剖宫产术的妊娠期糖尿病孕妇20例为GDM组。随机选择同期糖耐量正常孕妇20例为对照组(NGT)，两组孕妇年龄、孕周、体重指数比较，差异均无统汁学意义(P>0.05)。2组孕妇孕前均无高血压、心脏病、糖尿病及肝、肾等病史，且均为单胎、初产妇。
1.2 方法
抽取两组孕妇空腹肘静脉血及新生儿脐血约3 ml，静置2小时后以2000转每分钟，离心15分钟，取上清置于-80 ℃冰箱保存待测。采用酶联免疫吸附法(ELISA)测定血清及脐血RBP4水平，试剂盒由美国R&D公司提供。血脂由生化室统一测定。
1.3 统计学方法
应用spss 17.0软件进行统计学分析， 结果以?x ± s 表示，组间比较采用t 检验；指标间的关系判定采用直线相关分析。, 百拇医药(董金华)
【关键词】妊娠期糖尿病；视黄醇结合蛋白4(RBP4)；胎儿体重
, 百拇医药
【中图分类号】R714.256 【文献标识码】A 【文章编号】1004-7484(2012)10-0004-01
【Abstract 】Objective:To observe the changes of retinol binding protein 4(RBP4) in maternal serum levels and cord blood, and to assess their relationship with fetal weight in late trimester pregnant women with gestational diabetes mellitus(GDM).Methods:40 pregnant women who underwent elective cesarean section were recruited, including 20 with GDM and 20 with normal glucose tolerance test(NGT group). The serum and cord blood concentrations of RBP4 and total cholesterol,triglyceride were measured. Fetal weight were recorded. Statistical analysis was made by SPSS17.0.Results: (1)RBP4 levels both in maternal serum and cord blood were significantly higher in GDM group than in NGT group. (P<0.05;P=0.01); the cord blood concentrations of RBP4 were significantly lower than maternal serum(P<0.01); (2)compared with the control group, GDM group had heavier fetal weight (P<0.05);(3) The cord blood concentrations of RBP4 were also positively correlated with fetal weight (r=0.327,P<0.05); Conclusion: Maternal serum and cord blood RBP4 levels in GDM women had significant difference with NGT pregnancy women, and had positive correlation with fetal weight.This research hinted that RBP4 was closely correlated with GDM, and further study is needed to clarify its mechanism.
, 百拇医药
【Key words】Gestational diabetes mellitus(GDM);Retinol binding protein 4(RBP4); fetal weight
妊娠期糖尿病(GDM)是指妊娠期首次发现或发生的糖代谢异常。GDM对孕妇及胎儿均可造成不良影响。其发病机理尚未完全明确。近年来的研究表明,脂肪组织可分泌多种生物活性物质,称为脂肪因子。这些细胞因子与糖脂代谢的调节有重要关系。视黄醇结合蛋白4(RBP4)是一种新发现的脂肪因子，研究发现其与糖脂代谢密切相关。RBP4与妊娠期糖尿病的关系报道较少且有争议。本研究对GDM患者血清及脐血中的RBP4进行检测，以探讨RBP4与妊娠期糖尿病及胎儿体重的关系。
1 资料与方法
1.1 研究对象
依据美国糖尿病协会GDM标准进行诊断。选择2010年7月至2011年1月在本院门诊产前检查并行选择性剖宫产术的妊娠期糖尿病孕妇20例为GDM组。随机选择同期糖耐量正常孕妇20例为对照组(NGT)，两组孕妇年龄、孕周、体重指数比较，差异均无统汁学意义(P>0.05)。2组孕妇孕前均无高血压、心脏病、糖尿病及肝、肾等病史，且均为单胎、初产妇。
1.2 方法
抽取两组孕妇空腹肘静脉血及新生儿脐血约3 ml，静置2小时后以2000转每分钟，离心15分钟，取上清置于-80 ℃冰箱保存待测。采用酶联免疫吸附法(ELISA)测定血清及脐血RBP4水平，试剂盒由美国R&D公司提供。血脂由生化室统一测定。
1.3 统计学方法
应用spss 17.0软件进行统计学分析， 结果以?x ± s 表示，组间比较采用t 检验；指标间的关系判定采用直线相关分析。, 百拇医药(董金华)
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