视网膜中央动脉阻塞患者的凝血功能分析(1)
摘要：目的 分析视网膜中央动脉阻塞(central retinal artery occlusion，CRAO)患者的凝血功能情况，推测血栓形成是否是CRAO发病的主要危险因素。方法 回顾性研究将CRAO患者作为病变组，与之年龄、性别相匹配的普通人群作为对照组，进行凝血功能检查，将统计结果进行t检验，评价凝血功能差异是否有统计学意义及临床意义。结果 60例病变组与60例对照组凝血功能进行比较：49例男性病变组与49例男性对照组凝血功能进行比较，PT活动度、国际标准化比值、纤维蛋白原三项检查，差异具有统计学意义(P<0.05)，却无临床意义。11例女性病变组和11例女性对照组凝血功能检查，PT活动度和纤维蛋白原两项，差异具有统计学意义(P<0.05)，却无临床意义。结论 CRAO患者与普通人群相比，凝血功能检查结果差异无临床意义。CRAO患者无明显血栓形成倾向，进一步推测血栓形成不是CRAO的主要病因。
关键词：视网膜中央动脉阻塞；危险因素；凝血功能；凝血酶原时间；活化部分凝血活酶时间
, 百拇医药
Abstract：Objective To analyze the central retinal artery occlusion(central retinal artery occlusion，CRAO)the blood coagulation function of patients， whether that thrombosis is a major risk factor for the onset of CRAO.Methods A retrospective study of CRAO patients as the disease group，with age and sex matched normal people as control group，coagulation function examination，statistics the results of t test，the difference of coagulation function and clinical significance of evaluation of whether there is statistical significance.Results 60 cases of disease group and 60 cases of control group were compared with blood coagulation function：49 cases of male disease group and 49 cases of male control group blood coagulation function were compared，PT activity，international normalized ratio，fibrinogen three check，the difference was statistically significant(P<0.05)，but no clinical significance.11 cases of female disease group and 11 cases of female control group coagulation tests，PT activity and fibrinogen of two，the difference was statistically significant(P<0.05)，but no clinical significance.Conclusion The CRAO patients compared with the general population，coagulation function test results showed no clinical significance.CRAO patients had no tendency to thrombosis，further speculation that thrombosis is not the main cause of CRAO.
, 百拇医药
Key words：Central retinal artery occlusion；Risk factors；Coagulation function；Prothrombin time；Activated partial thromboplastin time
視网膜中央动脉阻塞(central retinal artery occlusion，CRAO)是眼科致盲性急症之一，预后差。病因仍不是十分明确，尚无公认有效的治疗方法。普遍认为该病的发生与栓子栓塞、血栓形成、血管炎症、动脉痉挛、外伤等因素有关，栓子栓塞和血栓形成是最为重要的两个因素。病因是治疗的前提，哪个因素更为重要，备受关注。栓子栓塞在国际上已被多次讨论，血栓形成报告较少，临床用于筛查是否有血栓形成、凝血机制是否正常的三项指标为：凝血酶原时间(prothrombin time，PT)、活化部分凝血活酶时间(activated partial thromboplatin time，APTT)和纤维蛋白原(Fibrinogen，FIB)。由于该病发病率较低，文献国内尚无视网膜中央动脉阻塞患者凝血分析的报告。本研究对60例患者和60例对照组进行凝血分析，为治疗提供依据。
1资料与方法
1.1一般资料 2001年1月～2016年7月在北京大学民航临床医学院确诊的CRAO患者60例，作为病变组；与之年龄、性别相匹配的普通人群60例作为对照组，进行凝血功能检查，病变组和对照组的年龄、性别具体情况见表1。
1.2纳入和排除标准 纳入标准：确诊为CRAO的患者。诊断标准：突然急剧的视力下降，间接检眼镜查眼底可见视网膜黄斑区呈现“樱桃红点”，视网膜灰白水肿，动脉变细，甚至部分中断，偶尔可见血管内的栓子。荧光血管造影显示视网膜动脉充盈迟缓。排除标准：合并其他眼底病：糖尿病视网膜病变、视网膜静脉阻塞；合并与凝血异常相关的疾病：白血病、产后大出血。, 百拇医药(王莹 胡庆军 刘涛 尚荣辉 邓青 刘国华 王巍)
关键词：视网膜中央动脉阻塞；危险因素；凝血功能；凝血酶原时间；活化部分凝血活酶时间
, 百拇医药
Abstract：Objective To analyze the central retinal artery occlusion(central retinal artery occlusion，CRAO)the blood coagulation function of patients， whether that thrombosis is a major risk factor for the onset of CRAO.Methods A retrospective study of CRAO patients as the disease group，with age and sex matched normal people as control group，coagulation function examination，statistics the results of t test，the difference of coagulation function and clinical significance of evaluation of whether there is statistical significance.Results 60 cases of disease group and 60 cases of control group were compared with blood coagulation function：49 cases of male disease group and 49 cases of male control group blood coagulation function were compared，PT activity，international normalized ratio，fibrinogen three check，the difference was statistically significant(P<0.05)，but no clinical significance.11 cases of female disease group and 11 cases of female control group coagulation tests，PT activity and fibrinogen of two，the difference was statistically significant(P<0.05)，but no clinical significance.Conclusion The CRAO patients compared with the general population，coagulation function test results showed no clinical significance.CRAO patients had no tendency to thrombosis，further speculation that thrombosis is not the main cause of CRAO.
, 百拇医药
Key words：Central retinal artery occlusion；Risk factors；Coagulation function；Prothrombin time；Activated partial thromboplastin time
視网膜中央动脉阻塞(central retinal artery occlusion，CRAO)是眼科致盲性急症之一，预后差。病因仍不是十分明确，尚无公认有效的治疗方法。普遍认为该病的发生与栓子栓塞、血栓形成、血管炎症、动脉痉挛、外伤等因素有关，栓子栓塞和血栓形成是最为重要的两个因素。病因是治疗的前提，哪个因素更为重要，备受关注。栓子栓塞在国际上已被多次讨论，血栓形成报告较少，临床用于筛查是否有血栓形成、凝血机制是否正常的三项指标为：凝血酶原时间(prothrombin time，PT)、活化部分凝血活酶时间(activated partial thromboplatin time，APTT)和纤维蛋白原(Fibrinogen，FIB)。由于该病发病率较低，文献国内尚无视网膜中央动脉阻塞患者凝血分析的报告。本研究对60例患者和60例对照组进行凝血分析，为治疗提供依据。
1资料与方法
1.1一般资料 2001年1月～2016年7月在北京大学民航临床医学院确诊的CRAO患者60例，作为病变组；与之年龄、性别相匹配的普通人群60例作为对照组，进行凝血功能检查，病变组和对照组的年龄、性别具体情况见表1。
1.2纳入和排除标准 纳入标准：确诊为CRAO的患者。诊断标准：突然急剧的视力下降，间接检眼镜查眼底可见视网膜黄斑区呈现“樱桃红点”，视网膜灰白水肿，动脉变细，甚至部分中断，偶尔可见血管内的栓子。荧光血管造影显示视网膜动脉充盈迟缓。排除标准：合并其他眼底病：糖尿病视网膜病变、视网膜静脉阻塞；合并与凝血异常相关的疾病：白血病、产后大出血。, 百拇医药(王莹 胡庆军 刘涛 尚荣辉 邓青 刘国华 王巍)