多种药物联合治疗白内障术后干眼症的临床效果观察(1)
摘要：目的 探讨多种药物联合治疗白内障术后干眼症的临床疗效。方法 选取2015年5月～2018年 9 月于我院行白内障手术术后干眼患者125例，随机分为A、B、C组三组，C组患者采用玻璃酸钠滴眼液治疗，A组在C组基础上加用贝复舒滴眼液治疗，B组在C组基础上加用普拉洛芬滴眼液治疗，比较各组患者治疗前后OSDI值、BUT、SIt值、FL的变化，比较各组患者治疗前后OSDI值、BUT、SIt值、FL的变化。结果 治疗后三组患者BUT，SIt值比较，差异有统计學意义(P<0.05);治疗后三组OSDI值，FL比较，差异无统计学意义(P>0.05);B组患者治疗的总有效率(95.24%)高于A组(93.02%)及C组(87.50%)，差异有统计学意义(P<0.05)。结论 玻璃酸钠滴眼液联合普拉洛芬滴眼液、玻璃酸钠滴眼液联合贝复舒滴眼液及单纯使用玻璃酸钠滴眼液均可减轻白内障术后干眼症患者的症状，增加泪液分泌量，延长泪膜破裂时间，使角膜染色降低，但玻璃酸钠滴眼液联合普拉洛芬滴眼液的治疗方案更佳。
关键词：白内障;干眼症;普拉洛芬;贝复舒
, 百拇医药
中图分类号：R779.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.046
文章编号：1006-1959(2019)04-0142-03
Abstract：Objective To investigate the clinical efficacy of multiple drugs in the treatment of xerophthalmiaafter cataract surgery. Methods A total of 125 patients with xerophthalmia who underwent cataract surgery in our hospital from May 2015 to September 2018 were randomly divided into three groups： group A， group B and group C. Patients in group C were treated with sodium hyaluronate eye drops. Group A was treated with Beifushu eye drops on the basis of group C. Group B was treated with pranoprofen eye drops on the basis of group C.The changes of OSDI， BUT， SIt and FL before and after treatment were compared between the groups. Results After treatment， the BUT and SIt values of the three groups were significantly different (P<0.05). There were no significant differences in the OSDI values and FL between the three groups after treatment (P>0.05). The effective rate (95.24%) was higher than that of group A (93.02%) and group C (87.50%)，the difference was statistically significant (P<0.05). Conclusion Sodium hyaluronate eye drops combined with pranoprofen eye drops， sodium hyaluronate eye drops combined with Beifushu eye drops and sodium hyaluronate eye drops alone can alleviate the symptoms of xerophthalmia patients after cataract surgery. Increase the amount of tear secretion， prolong the tear film rupture time， and reduce the cornea staining， but the treatment plan of sodium hyaluronate eye drops combined with pranoprofen eye drops is better.
, 百拇医药
Key words：Cataract;Xerophthalmia;Pranoprofen;Befushu
干眼症(xerophthalmia)是一种多因子疾病，其特征包括泪膜稳定性丧失并伴有干眼症状，其病因包括泪膜不稳定、泪液高渗性、眼表炎症与损伤和神经感觉异常等[1]。由于白内障手术导致泪膜破裂时间及稳定性发生改变、眼表结构遭到破坏，一部分患者术后出现视物模糊、眼干、眼异物感等不适症状。目前干眼症尚无特效治疗方法，主要是使用人工泪液补充，但是效果不佳;重组牛碱性成纤维细胞生长因子是贝复舒的主要成分，其广泛存在于细胞间质中，可减轻角膜上皮脱落，促进损伤的结膜和角膜上皮细胞修复。相关研究表明，眼表炎症可引起泪膜功能异常，导致干眼。普拉洛芬滴眼液为非甾体类抗炎药，主要通过抑制环氧化酶并阻断前列腺素等炎性介质的合成，抑制炎症[2，3]。本研究通过观察人工泪液与贝复舒滴眼液、普拉洛芬滴眼液与人工泪液及单用人工泪液治疗干眼症的临床疗效，为治疗白内障术后干眼提供参考。, 百拇医药(秦帅 侯光辉 祁冰)
关键词：白内障;干眼症;普拉洛芬;贝复舒
, 百拇医药
中图分类号：R779.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.046
文章编号：1006-1959(2019)04-0142-03
Abstract：Objective To investigate the clinical efficacy of multiple drugs in the treatment of xerophthalmiaafter cataract surgery. Methods A total of 125 patients with xerophthalmia who underwent cataract surgery in our hospital from May 2015 to September 2018 were randomly divided into three groups： group A， group B and group C. Patients in group C were treated with sodium hyaluronate eye drops. Group A was treated with Beifushu eye drops on the basis of group C. Group B was treated with pranoprofen eye drops on the basis of group C.The changes of OSDI， BUT， SIt and FL before and after treatment were compared between the groups. Results After treatment， the BUT and SIt values of the three groups were significantly different (P<0.05). There were no significant differences in the OSDI values and FL between the three groups after treatment (P>0.05). The effective rate (95.24%) was higher than that of group A (93.02%) and group C (87.50%)，the difference was statistically significant (P<0.05). Conclusion Sodium hyaluronate eye drops combined with pranoprofen eye drops， sodium hyaluronate eye drops combined with Beifushu eye drops and sodium hyaluronate eye drops alone can alleviate the symptoms of xerophthalmia patients after cataract surgery. Increase the amount of tear secretion， prolong the tear film rupture time， and reduce the cornea staining， but the treatment plan of sodium hyaluronate eye drops combined with pranoprofen eye drops is better.
, 百拇医药
Key words：Cataract;Xerophthalmia;Pranoprofen;Befushu
干眼症(xerophthalmia)是一种多因子疾病，其特征包括泪膜稳定性丧失并伴有干眼症状，其病因包括泪膜不稳定、泪液高渗性、眼表炎症与损伤和神经感觉异常等[1]。由于白内障手术导致泪膜破裂时间及稳定性发生改变、眼表结构遭到破坏，一部分患者术后出现视物模糊、眼干、眼异物感等不适症状。目前干眼症尚无特效治疗方法，主要是使用人工泪液补充，但是效果不佳;重组牛碱性成纤维细胞生长因子是贝复舒的主要成分，其广泛存在于细胞间质中，可减轻角膜上皮脱落，促进损伤的结膜和角膜上皮细胞修复。相关研究表明，眼表炎症可引起泪膜功能异常，导致干眼。普拉洛芬滴眼液为非甾体类抗炎药，主要通过抑制环氧化酶并阻断前列腺素等炎性介质的合成，抑制炎症[2，3]。本研究通过观察人工泪液与贝复舒滴眼液、普拉洛芬滴眼液与人工泪液及单用人工泪液治疗干眼症的临床疗效，为治疗白内障术后干眼提供参考。, 百拇医药(秦帅 侯光辉 祁冰)