PCT、IL-6和CRP水平预测未足月胎膜早破患者并发绒毛膜羊膜炎及新生儿早发性败血症的价值研究(1)
摘要：目的 观察联合检测PCT、IL-6和CRP水平预测未足月胎膜早破患者并发绒毛膜羊膜炎及新生儿早发性败血症的临床价值。方法 将2017年1月～2018年6月在我院治疗的70例未足月胎膜早破(PPROM)患者设为观察组，选取同期在我院产检孕周正常的70例孕妇设为对照组，根据病理检查将观察组分为绒毛膜羊膜炎组与无绒毛膜羊膜炎组，同时依据新生儿感染情况分为败血症组和非感染组。对比观察组和对照组外周血、脐血PCT、IL-6、CRP水平表达情况，并对观察组孕妇分娩后胎盘胎膜进行病理学检查以及追踪新生儿感染情况。结果 观察组孕妇外周血中PCT、IL-6、CRP水平均高于对照组，差异有统计学意义(P<0.05);无绒毛膜羊膜炎组PCT、IL-6、CRP水平低于绒毛膜羊膜炎组，差异有统计学意义(P<0.05);联合检测PCT、IL-6及CRP诊断绒毛膜羊膜炎的敏感性为68.75%、特异性为93.75%、阳性预测值为97.05%;脐血PCT、IL-6、CRP水平在败血症组新生儿中显著升高，与非感染组新生儿及对照组新生儿比较，差异有统计学意义(P<0.05)。结论 PPROM孕妇外周血PCT、IL-6、CRP水平较高，三项指标联合检测对绒毛膜羊膜炎预测价值高，脐血PCT、IL-6、CRP水平检测有利于早期诊断新生儿早发性败血症。
, 百拇医药
关键词：PCT;IL-6;CRP;胎膜早破;绒毛膜羊膜炎;新生儿早发性败血症
中图分类号：R714.433 文獻标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.054
文章编号：1006-1959(2019)04-0163-03
Abstract：Objective To observe the clinical value of combined detection of PCT， IL-6 and CRP levels in predicting chorioamnionitis and early onset sepsis in patients with premature rupture of fetal membranes. Methods 70 patients with premature rupture of fetal membranes (PPROM) who were treated in our hospital from January 2017 to June 2018 were enrolled in the observation group. 70 pregnant women who were normal in the gestational week of our hospital were selected as control group，according to pathological examination， the observation group was divided into chorioamnionitis group and non-chorioamnionitis group.At the same time， according to the neonatal infection， it was divided into sepsis group and non-infected group. The expressions of PCT， IL-6 and CRP in peripheral blood and cord blood were compared between the observation group and the control group. The pathological examination of the placenta membrane of the pregnant women in the observation group and the neonatal infection were followed. Results The levels of PCT， IL-6 and CRP in the peripheral blood of the pregnant women in the observation group were higher than those in the control group，the difference was statistically significant (P<0.05).The level of PCT，IL-6，CRP in non-chorioamnionitis group was significantly lower than that in chorioamnionitis group，the difference was statistically significant (P<0.05); the sensitivity of combined detection of PCT， IL-6 and CRP in the diagnosis of chorioamnionitis was 68.75%， specificity was 93.75%， positive predictive value was 97.05%; cord blood PCT， IL -6. The level of CRP was significantly increased in neonates in the septic group. Compared with the neonates in the non-infected group and the control group， the difference was statistically significant (P<0.05). Conclusion The peripheral blood of PPROM is higher in PCT， IL-6 and CRP. The combined detection of three indicators has high predictive value for chorioamnionitis. The detection of cord blood PCT， IL-6 and CRP levels is helpful for early diagnosis of early onset sepsis in neonates., 百拇医药(吴丕六 汤磊)
, 百拇医药
关键词：PCT;IL-6;CRP;胎膜早破;绒毛膜羊膜炎;新生儿早发性败血症
中图分类号：R714.433 文獻标识码：A DOI：10.3969/j.issn.1006-1959.2019.04.054
文章编号：1006-1959(2019)04-0163-03
Abstract：Objective To observe the clinical value of combined detection of PCT， IL-6 and CRP levels in predicting chorioamnionitis and early onset sepsis in patients with premature rupture of fetal membranes. Methods 70 patients with premature rupture of fetal membranes (PPROM) who were treated in our hospital from January 2017 to June 2018 were enrolled in the observation group. 70 pregnant women who were normal in the gestational week of our hospital were selected as control group，according to pathological examination， the observation group was divided into chorioamnionitis group and non-chorioamnionitis group.At the same time， according to the neonatal infection， it was divided into sepsis group and non-infected group. The expressions of PCT， IL-6 and CRP in peripheral blood and cord blood were compared between the observation group and the control group. The pathological examination of the placenta membrane of the pregnant women in the observation group and the neonatal infection were followed. Results The levels of PCT， IL-6 and CRP in the peripheral blood of the pregnant women in the observation group were higher than those in the control group，the difference was statistically significant (P<0.05).The level of PCT，IL-6，CRP in non-chorioamnionitis group was significantly lower than that in chorioamnionitis group，the difference was statistically significant (P<0.05); the sensitivity of combined detection of PCT， IL-6 and CRP in the diagnosis of chorioamnionitis was 68.75%， specificity was 93.75%， positive predictive value was 97.05%; cord blood PCT， IL -6. The level of CRP was significantly increased in neonates in the septic group. Compared with the neonates in the non-infected group and the control group， the difference was statistically significant (P<0.05). Conclusion The peripheral blood of PPROM is higher in PCT， IL-6 and CRP. The combined detection of three indicators has high predictive value for chorioamnionitis. The detection of cord blood PCT， IL-6 and CRP levels is helpful for early diagnosis of early onset sepsis in neonates., 百拇医药(吴丕六 汤磊)