【摘 要】 目的：比较不同厂家生产的盐酸小檗胺片在不同溶出介质中的溶出度。 方法：根据《中国药典》2015年版溶出度测定方法第二法，以人工胃液(不加酶)和人工肠液(不加酶)为溶出介质，转速为50 r/min，于279 nm处采用紫外分光光度法测定吸光度并计算溶出度，采用相似因子、主成分分析和分层聚类分析对溶出度进行数据分析。结果：盐酸小檗胺片在人工胃液(不加酶)和人工肠液(不加酶)中累积溶出度在40 %～50 %之间。结论：相似因子、主成分分析和分层聚类结果表明，在相同溶出条件下盐酸小檗胺糖衣片与薄膜衣片有不同的溶出行为，且薄膜衣片比糖衣片更加稳定，可见盐酸小檗胺薄膜衣片规格的工艺较糖衣片更加合理。

    【關键词】 盐酸小檗胺片；紫外分光光度法；溶出度；相似因子；主成分分析；分层聚类分析

    【中图分类号】R944.4 【文献标志码】 A【文章编号】1007-8517(2018)11-0026-07

    Abstract：Objective To compare the dissolution of Berbamine Hydrochloride tablets by different manufacturers in different dissolution media (artificial gastric and intestinal juice). Methods Samples were collected with the artificial gastric juice (without enzyme) and the artificial intestinal fluid (without enzyme) as solvent and rotation speed of 50r·min-1 according to second dissolution determination method(slurry method)stated in Chinese Pharmacopeia (2015 edition).The absorbance of samples was determined by UV spectrophotometry at detection wavelength of 279 nm.The data analysis about the dissolution was conducted by similarity factor ......