【摘 要】目的：分析研究维生素D3对小儿佝偻病的预防效果。方法：选择2015年3月～2017年2月于我院出生的佝偻病高危婴儿共260例为研究对象，根据婴儿入院单双号随机分为两组。对照组婴儿给予维生素D3干预，剂量为每日400IU。实验组婴儿给予维生素D3干预，剂量为每日800IU。对比观察两组婴儿不同时间点的血清磷脂酶活性、佝偻病检出率、1岁内前囟门闭合率、乳牙萌出时间。结果：实验组婴儿的不同时间点磷脂酶活性值均低于对照组，p<0.05，差异有统计学意义。实验组佝偻病检出率明显低于对照组，对比差异明显，p<0.05，差异有统计学意义。囟门闭合率、乳牙萌出时间，两组婴儿无明显差异p>0.05，结论：大剂量使用维生素D3可以有效的预防小儿佝偻病，尤其对佝偻病高危婴儿效果更好，并具有较高的安全性，值得应用。

    【关键词】维生素D3;小儿佝偻病;预防;囟门

    Abstract Objective： To analyze the preventive effect of vitamin D3 on rickets in children. Methods： A total of 260 high-risk infants with rickets born in our hospital from March 2015 to February 2017 were selected as subjects. They were randomly divided into two groups according to the number of infants admitted to the hospital. Infants in the control group were given vitamin D3 intervention at a dose of 400 IU per day. Infants in the experimental group were given vitamin D3 intervention at a dose of 800 IU per day. The serum phospholipase activity ......