[摘要] Nogo-A是近年来在中枢神经系统髓鞘中发现的一种抑制中枢神经轴突生长的蛋白，NgR作为Nogo-A的细胞表面受体而被发现。NgR与Nogo-A结合后通过一系列信号转导过程发挥抑制中枢神经再生的作用，与中枢神经系统损伤后的修复有着密切关系。对于Nogo-A及其受体NgR的深入研究，将有助于推动中枢神经系统损伤的治疗。

    [关键词] Nogo-A；NgR；中枢神经系统损伤

    [中图分类号] R651.1 [文献标识码] A [文章编号] 1673-7210(2012)01(a)-009-03

    The impaction of Nogo-A and its receptor NgR on central nervous system repair after injury

    GU Lei (review), ZHEN Yun (proofreader)

    Department of Neurosurgery, Xixiang People's Hospital Affiliated to Guangdong Medical College, Guangdong Province, Shenzhen 518102, China

    [Abstract] Nogo-A which is recently found in central nervous system (CNS) myelin sheath can inhibit the growth of nerve axon. NgR is found as the cell surface receptor of Nogo-A. The combination of NgR and Nogo-A can inhibit the neural regeneration in CNS through a series of signal conduction and has close relationship with CNS repair after injury. The thorough study of Nogo-A and NgR will help to promote the clinical treatment of CNS injury. ......