[摘要] 自噬是广泛存在于真核细胞中的生命现象，是生物体在其发育、老化过程中都存在的一个净化自身多余或受损细胞器的共同机制，生命体通过自噬清除细胞废物、进行结构重建以维持蛋白代谢平衡及细胞环境稳定。足细胞是肾脏固有细胞，其损伤是导致肾病蛋白尿和肾小球硬化的重要原因。PI3K-Akt/mTOR是广泛存在于足细胞内的重要信号通路，对足细胞自噬有一定调控作用。本文旨在对PI3K-Akt/mTOR信号通路与足细胞自噬的关系进行综述，以期探讨足细胞损伤所致肾病蛋白尿和肾小球硬化的治疗靶点。

    [关键词] 足细胞；自噬；信号通路；肾脏病

    [中图分类号] R329.2 [文献标识码] A [文章编号] 1673-7210(2016)03(c)-0084-04

    [Abstract] Autophagy is a life phenomenon widely exists in eukaryotic cells. It is the common mechanism of biosome that purify its excess or damaged organelle during the process of growth and aging. Organism can remove the cell waste by autophagy and reconstruct the structure in order to maintain the balance of protein metabolism and stable cell environment. Podocyte is the inherent cells of kidney. Podocyte injury is a major cause of nephrotic proteinuria and glomerular sclerosis. PI3K-Akt/mTOR is an important signaling pathway exists in podocytes ......