放疗同步化疗治疗宫颈癌的临床效果(1)
[摘要] 目的 研究放疗同步化疗治疗宫颈癌的临床效果。 方法 方便选择该院2017年3月—2019年8月收治的40例宫颈癌患者，数字表法随机分组，对照组进行调强适形放疗，实验组放疗同步化疗，对比治疗效果和不良反应。 结果 实验组治疗总有效率95.00%高于对照组的70.00%，结果对比差异有统计学意义(χ2=4.330，P=0.030);实验组1年生存率90.00%高于对照组的70.00%，局部复发率15.00%低于对照组的35.00%，远处转移率10.00%低于对照组的25.00%，结果对比差异有统计学意义(P<0.05);实验组白细胞减少，血红蛋白降低，恶心呕吐，纳差乏力等不良反应发生率高于对照组，结果对比差异有统计学意义(P<0.05)。结论 放疗同期使用化疗药物对宫颈癌有显著疗效。
[关键词] 宫颈癌;放疗;化疗;紫杉醇;奈达铂
[Abstract] Objective To study the clinical effect of concurrent radiotherapy and chemotherapy on cervical cancer. Methods Convenient select 40 cervical cancer patients who were treated in the department from March 2017 to August 2019 were randomly divided into groups according to the digital table method. The control group received intensity-modulated conformal radiotherapy and the experimental group received concurrent radiotherapy for chemotherapy. The treatment effects and adverse reactions were compared. Results The total effective rate of treatment in the experimental group was 95.00% higher than 70.00% in the control group. The difference was statistically significant(χ2=4.330， P=0.03). The one-year survival rate of the experimental group was 90.00% higher than the control group's 70.00%， The local recurrence rate was 15.00% lower than the control group's 35.00%， and the distant metastasis rate was 10.00% lower than the control group's 25.00%. The difference was statistically significant(P<0.05); the experimental group had reduced white blood cells and reduced hemoglobin. The incidence of adverse reactions such as nausea， vomiting， and fatigue was higher than that of the control group， The difference was statistically significant(P<0.05). Conclusion Concomitant use of chemotherapeutic drugs in radiotherapy has a significant effect on cervical cancer.
[Key words] Cervical cancer; Radiotherapy; Chemotherapy; Paclitaxel; Nedaplatin
宫颈癌属于妇科的常见肿瘤，在女性恶性肿瘤中具有较高的发病率，研究显示[1]，我国宫颈癌新发病例占所有女性肿瘤的13%左右。宫颈癌发病的病因尚未完全明确，目前已经确定的病因包括：病毒感染，常见于高危型HPV感染，病毒感染导致的宫颈癌在临床上较多;性行为年龄过早、分娩次数过多导致宫颈癌，据临床资料统计，女性在16岁以前发生性行为易发生宫颈癌[2];单纯疱疹、沙眼衣原体等病菌感染导致宫颈癌，病菌在子宫内繁殖力较强;营养不良、不注意个人卫生易导致宫颈癌。宫颈癌会严重威胁女性健康，发现此疾病需及时治疗，制定治疗方案时，应充分考虑患者的个体情况与临床分期，遵循“手术、放疗为主，化疗为辅”的治疗原则[3]。研究指出[4]，放疗適用于中晚期患者，手术适用于早期患者，同时，针对不适宜采取手术治疗的患者，也可进行放疗。单纯放疗的效果较差，5年生存率在40%～50%之间[5]。因此，综合治疗在宫颈癌患者中占据越来越重要的地位。该研究方便选取2017年3月—2019年8月在该院接受治疗的宫颈癌患者，探讨放疗同步化疗治疗宫颈癌的临床效果，现报道如下。
1 资料与方法
1.1 一般资料
方便收集该院接受治疗的宫颈癌患者，于其中选取40例作为研究对象。在获取医院伦理委员会批准、患者签署知情同意书之后，将之按照数字表法随机对40例患者分组，每组均为20例。对照组最小年龄49岁，最大年龄85岁，平均(63.2±8.6)岁;3例腺癌，17例鳞癌。实验组最小年龄45岁，最大年龄76岁，平均(63.3±8.5)岁;4例腺癌，16例鳞癌。两组患者临床资料差异无统计学意义(P>0.05)，可对比。, 百拇医药(蒋富琴)
[关键词] 宫颈癌;放疗;化疗;紫杉醇;奈达铂
[Abstract] Objective To study the clinical effect of concurrent radiotherapy and chemotherapy on cervical cancer. Methods Convenient select 40 cervical cancer patients who were treated in the department from March 2017 to August 2019 were randomly divided into groups according to the digital table method. The control group received intensity-modulated conformal radiotherapy and the experimental group received concurrent radiotherapy for chemotherapy. The treatment effects and adverse reactions were compared. Results The total effective rate of treatment in the experimental group was 95.00% higher than 70.00% in the control group. The difference was statistically significant(χ2=4.330， P=0.03). The one-year survival rate of the experimental group was 90.00% higher than the control group's 70.00%， The local recurrence rate was 15.00% lower than the control group's 35.00%， and the distant metastasis rate was 10.00% lower than the control group's 25.00%. The difference was statistically significant(P<0.05); the experimental group had reduced white blood cells and reduced hemoglobin. The incidence of adverse reactions such as nausea， vomiting， and fatigue was higher than that of the control group， The difference was statistically significant(P<0.05). Conclusion Concomitant use of chemotherapeutic drugs in radiotherapy has a significant effect on cervical cancer.
[Key words] Cervical cancer; Radiotherapy; Chemotherapy; Paclitaxel; Nedaplatin
宫颈癌属于妇科的常见肿瘤，在女性恶性肿瘤中具有较高的发病率，研究显示[1]，我国宫颈癌新发病例占所有女性肿瘤的13%左右。宫颈癌发病的病因尚未完全明确，目前已经确定的病因包括：病毒感染，常见于高危型HPV感染，病毒感染导致的宫颈癌在临床上较多;性行为年龄过早、分娩次数过多导致宫颈癌，据临床资料统计，女性在16岁以前发生性行为易发生宫颈癌[2];单纯疱疹、沙眼衣原体等病菌感染导致宫颈癌，病菌在子宫内繁殖力较强;营养不良、不注意个人卫生易导致宫颈癌。宫颈癌会严重威胁女性健康，发现此疾病需及时治疗，制定治疗方案时，应充分考虑患者的个体情况与临床分期，遵循“手术、放疗为主，化疗为辅”的治疗原则[3]。研究指出[4]，放疗適用于中晚期患者，手术适用于早期患者，同时，针对不适宜采取手术治疗的患者，也可进行放疗。单纯放疗的效果较差，5年生存率在40%～50%之间[5]。因此，综合治疗在宫颈癌患者中占据越来越重要的地位。该研究方便选取2017年3月—2019年8月在该院接受治疗的宫颈癌患者，探讨放疗同步化疗治疗宫颈癌的临床效果，现报道如下。
1 资料与方法
1.1 一般资料
方便收集该院接受治疗的宫颈癌患者，于其中选取40例作为研究对象。在获取医院伦理委员会批准、患者签署知情同意书之后，将之按照数字表法随机对40例患者分组，每组均为20例。对照组最小年龄49岁，最大年龄85岁，平均(63.2±8.6)岁;3例腺癌，17例鳞癌。实验组最小年龄45岁，最大年龄76岁，平均(63.3±8.5)岁;4例腺癌，16例鳞癌。两组患者临床资料差异无统计学意义(P>0.05)，可对比。, 百拇医药(蒋富琴)
参见：首页 > 医疗版 > 疾病专题 > 妇产科 > 女性生殖器官肿瘤及肿瘤样病变 > 子宫颈癌