TREM2基因与中国福建阿尔茨海默病患者相关性分析(5)
[20] Le Ber I，De Septenville A，Guerreiro R，et al.Homozygous TREM2 mutation in a family with atypical frontotemporal dementia[J].Neurobiol Aging，2014，35(10)：2419-2423.
[21] Yeh F L，Hansen D V，Sheng M.TREM2，Microglia，and Neurodegenerative Diseases[J].Trends Mol Med，2017，23(6)：512-533.
[22] Gorenjak V，Aldasoro Arguinano A A，Dade S，et al.The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-αlevels and IMT-F[J].Sci Rep，2018，8(1)：7160.
[23] Wang M，Gao X，Zhao K，et al.Effect of TREM2 on Release of Inflammatory Factor from LPS-stimulated Microglia and Its Possible Mechanism[J].Ann Clin Lab Sci，2019，49(2)：249-256.
[24] Mazaheri F，Snaidero N，Kleinberger G，et al.TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury[J].EMBO Rep，2017，18(7)：1186-1198.
[25] Kleinberger G，Yamanishi Y，Suarez-Calvet M，et al.TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis[J].Sci Transl Med，2014，6(243)：243-286.
[26] Schindler S E，Holtzman D M.CSF sTREM2：marking the tipping point between preclinical AD and dementia？[J].EMBO Mol Med，2016，8(5)：437-438.
[27] Zhong L，Xu Y，Zhuo R，et al.Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model[J].Nat Commun，2019，10(1)：1365.
(收稿日期：2019-05-20) (本文編辑：程旭然), 百拇医药(江斌?毕敏?马琪林?童绥君)
[21] Yeh F L，Hansen D V，Sheng M.TREM2，Microglia，and Neurodegenerative Diseases[J].Trends Mol Med，2017，23(6)：512-533.
[22] Gorenjak V，Aldasoro Arguinano A A，Dade S，et al.The polymorphism rs6918289 located in the downstream region of the TREM2 gene is associated with TNF-αlevels and IMT-F[J].Sci Rep，2018，8(1)：7160.
[23] Wang M，Gao X，Zhao K，et al.Effect of TREM2 on Release of Inflammatory Factor from LPS-stimulated Microglia and Its Possible Mechanism[J].Ann Clin Lab Sci，2019，49(2)：249-256.
[24] Mazaheri F，Snaidero N，Kleinberger G，et al.TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury[J].EMBO Rep，2017，18(7)：1186-1198.
[25] Kleinberger G，Yamanishi Y，Suarez-Calvet M，et al.TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis[J].Sci Transl Med，2014，6(243)：243-286.
[26] Schindler S E，Holtzman D M.CSF sTREM2：marking the tipping point between preclinical AD and dementia？[J].EMBO Mol Med，2016，8(5)：437-438.
[27] Zhong L，Xu Y，Zhuo R，et al.Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model[J].Nat Commun，2019，10(1)：1365.
(收稿日期：2019-05-20) (本文編辑：程旭然), 百拇医药(江斌?毕敏?马琪林?童绥君)