胃食管反流性咳嗽与焦虑、抑郁状态相关性分析(1)
【摘要】 目的：調查胃食管反流性咳嗽(gastroesophageal reflux cough，GERC)的精神心理状态，探讨其与GERC相关性。方法：对就诊福建省立医院疑似胃食管反流(gastroesophageal reflux disease，GERD)患者进行高分辨食管测压及24 h pH及阻抗监测，确诊的GERC组患者42例，典型GERD组患者34例，对照组34例，并根据焦虑自评量表(self-rating anxiety scale，SAS)、抑郁自评量表(self-rating depression scale，SDS)将GERC组分为无焦虑抑郁组、有焦虑抑郁组，探讨GERC组、典型GERD组、对照组焦虑抑郁状态的不同，以及焦虑抑郁状态对GERC患者食管动力的影响。结果：42.2%GERC患者有不同程度的焦虑和抑郁。GERC组轻中度焦虑抑郁比例(42.9%)高于对照组(17.6%)，典型GERD组焦虑抑郁程度明显高于GERC组，且以中重度焦虑抑郁为主(50.0%)，差异均有统计学意义(P<0.05)。GERC患者中，有焦虑抑郁组上食管括约肌压力(pressure of upper esophageal sphincter，UESP)低于无焦虑抑郁组，差异有统计学意义(P<0.05)。GERC患者UESP与焦虑抑郁相关(r=-0.381)。结论：GERC患者存在焦虑抑郁状态，且焦虑抑郁状态与UESP呈负相关。
【关键词】 胃食管反流性咳嗽； 典型胃食管反流； 高分辨率食管测压； 焦虑； 抑郁； 食管动力
doi：10.14033/j.cnki.cfmr.2018.25.004 文献标识码 A 文章编号 1674-6805(2018)25-000-03
【Abstract】 Objective：To investigate the mental status of gastroesophageal reflux cough(GERC) and investigate its association with GERC.Method：High-resolution esophageal manometry and 24-hour pH and impedance monitoring were performed on patients with suspected gastroesophageal reflux(GERD) in Fujian Provincial Hospital.42 patients with GERC were diagnosed，34 patients with typical GERD，and 34 cases as the control group.According to the anxiety self-rating scale(SAS) and self-rating depression scale(SDS) scores，they were divided into non-anxiety and depression group and anxiety and depression group.The difference of anxiety and depression，and the affect of anxiety and depression on esophageal motility in patients with GERC were investigated among the GERC group，typical GERD group and control group.Result：About 45.2% patients with GERC had different degrees of anxiety and depression.The proportion of mild to moderate anxiety and depression (42.9%) in GERC group was higher than that of the control group (17.6%)；the anxiety and depression in the typical GERD group was significantly higher than that in the GERC group，and the main symptoms were moderate to severe anxiety and depression(50.0%)；the differences were statistically significant(P<0.05).In GERC group，the upper esophageal sphincter pressure(UESP) in patients with anxiety and depression was lower than that in the non-anxiety depression group，the difference was statistically significant(P<0.05).UESP in GERC patients was associated with anxiety and depression(r=-0.381).Conclusion：Anxiety and depression is existed in GERC patients，and anxiety and depression were negatively correlated with UESP.
【Key words】 Gastroesophageal reflux cough； Typical gastroesophageal reflux； High-resolution esophageal manometry； Anxiety； Depression； Esophageal motility, 百拇医药(曾艳凌 林晗 黄胡萍)
【关键词】 胃食管反流性咳嗽； 典型胃食管反流； 高分辨率食管测压； 焦虑； 抑郁； 食管动力
doi：10.14033/j.cnki.cfmr.2018.25.004 文献标识码 A 文章编号 1674-6805(2018)25-000-03
【Abstract】 Objective：To investigate the mental status of gastroesophageal reflux cough(GERC) and investigate its association with GERC.Method：High-resolution esophageal manometry and 24-hour pH and impedance monitoring were performed on patients with suspected gastroesophageal reflux(GERD) in Fujian Provincial Hospital.42 patients with GERC were diagnosed，34 patients with typical GERD，and 34 cases as the control group.According to the anxiety self-rating scale(SAS) and self-rating depression scale(SDS) scores，they were divided into non-anxiety and depression group and anxiety and depression group.The difference of anxiety and depression，and the affect of anxiety and depression on esophageal motility in patients with GERC were investigated among the GERC group，typical GERD group and control group.Result：About 45.2% patients with GERC had different degrees of anxiety and depression.The proportion of mild to moderate anxiety and depression (42.9%) in GERC group was higher than that of the control group (17.6%)；the anxiety and depression in the typical GERD group was significantly higher than that in the GERC group，and the main symptoms were moderate to severe anxiety and depression(50.0%)；the differences were statistically significant(P<0.05).In GERC group，the upper esophageal sphincter pressure(UESP) in patients with anxiety and depression was lower than that in the non-anxiety depression group，the difference was statistically significant(P<0.05).UESP in GERC patients was associated with anxiety and depression(r=-0.381).Conclusion：Anxiety and depression is existed in GERC patients，and anxiety and depression were negatively correlated with UESP.
【Key words】 Gastroesophageal reflux cough； Typical gastroesophageal reflux； High-resolution esophageal manometry； Anxiety； Depression； Esophageal motility, 百拇医药(曾艳凌 林晗 黄胡萍)