【摘 要】目的：观察肿瘤坏死因子-α(TNF-α)抑制剂对类风湿关节炎患者血清中高密度脂蛋白(HDL)水平的影响。方法：将43例类风湿关节炎患者分为治疗组23例和对照组20例。治疗组采用甲氨蝶呤联合TNF-α抑制剂治疗，对照组采用甲氨蝶呤治疗。检测2组治疗前及治疗2周、3个月后血清HDL水平。结果：治疗2周后治疗组HDL水平较治疗前升高(P < 0.01)，但治疗3个月后HDL水平较治疗前无明显变化(P > 0.05)。对照组治疗2周后和3个月后HDL水平较治疗前均无明显变化(P > 0.05)。结论：TNF-α抑制剂治疗能短暂性升高类风湿关节炎患者血清HDL水平。

    【关键词】 关节炎，类风湿；肿瘤坏死因子-α抑制剂；高密度脂蛋白

    【ABSTRACT】Objective：To observe the effect of TNF-α inhibitor on the level of serum high density lipoprotein in patients with rheumatoid arthritis.Methods：Forty three patients with rheumatoid arthritis were divided into a treatment group(23 cases)and a control group(20 cases).The treatment group was treated with methotrexate combined with TNF-α inhibitor ......