生酮饮食的抗癫_机制研究进展.pdf
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activator2 plasmin system in the hippocampus[J ] . J Neurosci ,2002 ,22 (6) :
21252 2134.
4 Tsirka SE. Tissue plasminogen activator as a modulator of neuronal survival
and function[J ] .Biol Soc Trans ,2002 ,30 (2) :2222225.
5 Tsirka SE. Clinical implication of the involvement of tPA in neuronal cell
death[J ] . J Mol Med ,1997 ,75 (5) :3412347.
6 Seeds NW,Williams BL ,Bickford PC , et al . Tissue plasminogen activator
induction in purkinje neurons after cerebellar motor learning [J ] . Science ,1995 ,270 (5244) :199221994.
7 Ahn MY, Zhang ZG, Tsang W, et al . Endogenous plasminogen activator
expression after embolic focal cerebral ischemia in mice [ J ] . Brain Res ,1999 ,837 (122) :1692176.
8 Lin TN ,Wang CK, Cheung WM, et al . Induction of angiopoietin and tie
receptor mRNA expression after cerebral ischemia reperfusion [J ] . J Cereb
Blood Flow Metab ,2000 ,20(2) :3872395.
9 Ito T ,Takenaka K,Sakai H ,et al . Elevation of mRNA levels of tissue2type
plasminogen activator and urokinase2type plasminogen activator in
hippocampus and cerebral cortex following middle cerebral artery occlusion in
rats[J ] . Neurol Res ,2000 ,22 (4) :4132419.
10 Wang YF ,Triska SE ,Strickland S ,et al . Tissue plasminogen activator (TPA)
increase neuronal damage after focal cerebral ischemia in wild2type and tPA2
deficient mice[J ] . Nature Med ,1998 ,4 (2) :2282231.
11 Flavin MP , Zhao G. Tissue plasminogen activator protects hippocampal
neurons from oxygen2glucose deprivation injury[J ] . J Neurosci Res ,2001 ,63
(5) :3882394.
12 Hosomi N , Lucero J , Heo JH , et al . Rapid differential endogenous
plasminogen activator expression after acute middle cerebral artery occlusion
[J ] . Stroke ,2001 ,32 (6) :134121348.
13 Muramatsu K,Fukuda A ,Togari H ,et al . Vulnerability to cerebral hypoxic2
ischemic insult in neonatal but not in adult rats is in parallel with disruption
of the blood2brain barrier[J ] . Strock ,1997 ,28 (11) :228122289.
14 Yepes M, Sandkvist M, Moore EG, et al . Tissue plasminogen activator
induces opening of the blood2brain barrier via the LDL receptor2related
protein[J ] . J Clin Invest ,2003 ,112(10) :153321540.
15 Whitelaw A , Mowinckel MC , Fellmon V , et al . Endogenous tissue
plasminogen activator in neonatal cerebrospinal fluid [ J ] . Eur J Pediatr ,1996 ,155 (2) :1172119.
16 Tsirka SE ,Rogove AD ,Bugge TH ,et al . An extracellular proteolytic cascade
promotes neuronal degeneration in the mouse hippocampus[J ] . J Neurosci ,1997 ,17 (2) :5432552.
17 Nicole O , Docagne F , Ali C , et al . The proteolytic activity of tissue2
plaminogen activator enhances NMDA receptor2mediated signaling [J ] . Nat
Med ,2001 ,7 (1) :59264.
18 Kohmura E , Yuguchi T , Sakaki T , et al . Changes in tissue2 plasminogen
activator mRNA expression following cortical ablation in the rat brain[J ] . J
Mol Neurosci ,2000 ,14 (122) :53259.
19 Nagai N ,Yamamoto S ,Tsuboi T ,et al . Tissue2type plasminogen activator is
involved in the process of neuronal death induced by oxygen2glucose
deprivation in culture [J ] . J Cereb Blood Flow Metab ,2001 ,21 (6) : 6312
634.
20 Siao CJ , Tsirke SE. Tissue plasminogen activator mediates microglial
activation via its finger domain through annexin II[J ] . J Neurosci ,2002 ,22
(9) :335223358.
(收稿日期:2004207205)
(本文编辑:李巍)
生酮饮食的抗癫疒 间机制研究进展 Progress in the Antiepileptic Mechanism Research of Ketogenic Diet Treatment
徐向平(综述) 孙若鹏(审校)
(山东大学齐鲁医院 ,济南 250012)
【摘要】 生酮饮食(KD)是一种高脂、低糖饮食 ,虽然 KD的疗效早已明确 ,但其作用机制尚不清楚 ......
21252 2134.
4 Tsirka SE. Tissue plasminogen activator as a modulator of neuronal survival
and function[J ] .Biol Soc Trans ,2002 ,30 (2) :2222225.
5 Tsirka SE. Clinical implication of the involvement of tPA in neuronal cell
death[J ] . J Mol Med ,1997 ,75 (5) :3412347.
6 Seeds NW,Williams BL ,Bickford PC , et al . Tissue plasminogen activator
induction in purkinje neurons after cerebellar motor learning [J ] . Science ,1995 ,270 (5244) :199221994.
7 Ahn MY, Zhang ZG, Tsang W, et al . Endogenous plasminogen activator
expression after embolic focal cerebral ischemia in mice [ J ] . Brain Res ,1999 ,837 (122) :1692176.
8 Lin TN ,Wang CK, Cheung WM, et al . Induction of angiopoietin and tie
receptor mRNA expression after cerebral ischemia reperfusion [J ] . J Cereb
Blood Flow Metab ,2000 ,20(2) :3872395.
9 Ito T ,Takenaka K,Sakai H ,et al . Elevation of mRNA levels of tissue2type
plasminogen activator and urokinase2type plasminogen activator in
hippocampus and cerebral cortex following middle cerebral artery occlusion in
rats[J ] . Neurol Res ,2000 ,22 (4) :4132419.
10 Wang YF ,Triska SE ,Strickland S ,et al . Tissue plasminogen activator (TPA)
increase neuronal damage after focal cerebral ischemia in wild2type and tPA2
deficient mice[J ] . Nature Med ,1998 ,4 (2) :2282231.
11 Flavin MP , Zhao G. Tissue plasminogen activator protects hippocampal
neurons from oxygen2glucose deprivation injury[J ] . J Neurosci Res ,2001 ,63
(5) :3882394.
12 Hosomi N , Lucero J , Heo JH , et al . Rapid differential endogenous
plasminogen activator expression after acute middle cerebral artery occlusion
[J ] . Stroke ,2001 ,32 (6) :134121348.
13 Muramatsu K,Fukuda A ,Togari H ,et al . Vulnerability to cerebral hypoxic2
ischemic insult in neonatal but not in adult rats is in parallel with disruption
of the blood2brain barrier[J ] . Strock ,1997 ,28 (11) :228122289.
14 Yepes M, Sandkvist M, Moore EG, et al . Tissue plasminogen activator
induces opening of the blood2brain barrier via the LDL receptor2related
protein[J ] . J Clin Invest ,2003 ,112(10) :153321540.
15 Whitelaw A , Mowinckel MC , Fellmon V , et al . Endogenous tissue
plasminogen activator in neonatal cerebrospinal fluid [ J ] . Eur J Pediatr ,1996 ,155 (2) :1172119.
16 Tsirka SE ,Rogove AD ,Bugge TH ,et al . An extracellular proteolytic cascade
promotes neuronal degeneration in the mouse hippocampus[J ] . J Neurosci ,1997 ,17 (2) :5432552.
17 Nicole O , Docagne F , Ali C , et al . The proteolytic activity of tissue2
plaminogen activator enhances NMDA receptor2mediated signaling [J ] . Nat
Med ,2001 ,7 (1) :59264.
18 Kohmura E , Yuguchi T , Sakaki T , et al . Changes in tissue2 plasminogen
activator mRNA expression following cortical ablation in the rat brain[J ] . J
Mol Neurosci ,2000 ,14 (122) :53259.
19 Nagai N ,Yamamoto S ,Tsuboi T ,et al . Tissue2type plasminogen activator is
involved in the process of neuronal death induced by oxygen2glucose
deprivation in culture [J ] . J Cereb Blood Flow Metab ,2001 ,21 (6) : 6312
634.
20 Siao CJ , Tsirke SE. Tissue plasminogen activator mediates microglial
activation via its finger domain through annexin II[J ] . J Neurosci ,2002 ,22
(9) :335223358.
(收稿日期:2004207205)
(本文编辑:李巍)
生酮饮食的抗癫疒 间机制研究进展 Progress in the Antiepileptic Mechanism Research of Ketogenic Diet Treatment
徐向平(综述) 孙若鹏(审校)
(山东大学齐鲁医院 ,济南 250012)
【摘要】 生酮饮食(KD)是一种高脂、低糖饮食 ,虽然 KD的疗效早已明确 ,但其作用机制尚不清楚 ......
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