高容量血液滤过对MODS患者细胞因子及SOFA评分的影响
http://www.100md.com
高容量血液滤过对MODS患者细胞因子及SOFA评分的影响
郑晓英 刘德红 魏刚 呉华雄
深圳市第二人民医院急诊科，广东 深圳 518035
【摘要】 目的 观察高容量血液滤过对多器官功能障碍综合征(multiple organ dysfunction syndrome，MODS)患者细胞因子及序贯器官衰竭估计(sequential organ failure assessment，SOFA)评分的影响，探讨高容量血液滤过对MODS患者的治疗作用。方法 31名行高容量血液滤过治疗的MODS患者为研究对象，比较他们治疗前后细胞因子TNF-α、IL-6、IL-8的水平和SOFA评分的变化。结果 高容量血液滤过治疗后的MODS患者其细胞因子TNF-α、IL-6、IL-8的水平及SOFA评分与治疗前比较明显降低，差异有显著性意义(t=12.47, 14.85, 10.60, 8.87, P < 0.05))。结论 高容量血液滤过能降低MODS患者细胞因子水平，降低MODS患者的SOFA评分，可改善MODS患者的预后。
【关键词】 高容量血液滤过；多器官功能障碍综合征；细胞因子; 序贯器官衰竭估计评分
Effects of high-volume hemofiltration on the cytokines and sequential organ failure assessment scores in patients with multiple organ dysfunction syndrome
[Abstract] Objective To observe the effects of high-volume hemofiltration(HVHF) on the cytokines and sequential organ failure assessment(SOFA) scores in patients with multiple organ dysfunction syndrome and to investigate the therapeutic action of HVHF on patients with MODS. Methods Thirty-one patients with MODS underwent HVHF were brought into trial. The levels of TNF-α,IL-6,IL-8 and the SOFA scores in patients with MODS were measured before HVHF and after HVHF respectively. Result The levels of TNF-α,IL-6,IL-8 and the SOFA scores in patients with MODS before HVHF were higher than those after HVHF (t=12.47, 14.85, 10.60, 8.87,, respectively, P < 0.05). Conclusions HVHF could decrease the levels of cytokines and the SOFA scores in patients with MODS, and improve the survival rate of MODS patients. ......
郑晓英 刘德红 魏刚 呉华雄
深圳市第二人民医院急诊科，广东 深圳 518035
【摘要】 目的 观察高容量血液滤过对多器官功能障碍综合征(multiple organ dysfunction syndrome，MODS)患者细胞因子及序贯器官衰竭估计(sequential organ failure assessment，SOFA)评分的影响，探讨高容量血液滤过对MODS患者的治疗作用。方法 31名行高容量血液滤过治疗的MODS患者为研究对象，比较他们治疗前后细胞因子TNF-α、IL-6、IL-8的水平和SOFA评分的变化。结果 高容量血液滤过治疗后的MODS患者其细胞因子TNF-α、IL-6、IL-8的水平及SOFA评分与治疗前比较明显降低，差异有显著性意义(t=12.47, 14.85, 10.60, 8.87, P < 0.05))。结论 高容量血液滤过能降低MODS患者细胞因子水平，降低MODS患者的SOFA评分，可改善MODS患者的预后。
【关键词】 高容量血液滤过；多器官功能障碍综合征；细胞因子; 序贯器官衰竭估计评分
Effects of high-volume hemofiltration on the cytokines and sequential organ failure assessment scores in patients with multiple organ dysfunction syndrome
[Abstract] Objective To observe the effects of high-volume hemofiltration(HVHF) on the cytokines and sequential organ failure assessment(SOFA) scores in patients with multiple organ dysfunction syndrome and to investigate the therapeutic action of HVHF on patients with MODS. Methods Thirty-one patients with MODS underwent HVHF were brought into trial. The levels of TNF-α,IL-6,IL-8 and the SOFA scores in patients with MODS were measured before HVHF and after HVHF respectively. Result The levels of TNF-α,IL-6,IL-8 and the SOFA scores in patients with MODS before HVHF were higher than those after HVHF (t=12.47, 14.85, 10.60, 8.87,, respectively, P < 0.05). Conclusions HVHF could decrease the levels of cytokines and the SOFA scores in patients with MODS, and improve the survival rate of MODS patients. ......